In this miniature, the prince is wearing the ribbon and star of the order of the Garter. The princess has a miniature of the prince in the bracelet she is wearing on her right wrist, and a similar brooch on her dress. In the background are the Prince of Wales' feathers over an apple and sprays of blossom. The miniature refers to the marriage of the prince and princess on 27 April 1736. They are holding hands, as in fede (faith) rings, which had long symbolised good faith, with a particular association with marriage. As the inscription on the reverse suggests, the idea for the double portrait may have been taken from the engraving illustrating the Prince of Wales' obituary in The Gentleman's Magazine for April 1751 which shows the sitters in the same relation to each other but within separate ovals. The source of the engraving is G.W. Vestner's silver medal struck in Nuremberg to commemorate the marriage and John Kirk's silver medal issued in 1746.

Gaetano Manini (c. 1730-c. 1780/90) was a Milanese history painter and miniaturist. He is said to have studied at the Academy of Bologna under Donato Creti before coming to England around 1750. He exhibited at the Free Society of Artists from 1761 to 1772 and at the Society of Artists of Great Britain from 1762 to 1775 and also spent some time working in Ireland. His paintings included an allegory of the foundation of the Royal Academy by George III in 1768.

Inscribed on the reverse: P.D.G. Mati 1736/Fato. Lapresente / Nel 1758 / secondo / La idea che / Ho veduto / Di Me Gaetano / Manini Milanese / 1758.— (Princeps Deo Gratia Mariti 1738 / painted in 1758 after a picture I have seen / by me Gaetano Manini of Milan / 1758).